
Białko mitochondrialne CMPK2 reguluje tworzenie
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Białko mitochondrialne CMPK2 reguluje tworzenie komórek piankowatych wzmocnionych przez IFN alfa, potencjalnie przyczyniając się do przedwczesnej miażdżycy tętnic w SLE
Background: Untimely atherosclerosis happens in sufferers with SLE; nonetheless, the mechanisms stay unclear. Each mitochondrial equipment and proinflammatory cytokine interferon alpha (IFN-α) probably contribute to atherogenic processes in SLE. Right here, we discover the roles of the mitochondrial protein cytidine/uridine monophosphate kinase 2 (CMPK2) in IFN-α-mediated pro-atherogenic occasions.
Strategies: Foam cell measurements have been carried out by oil purple O staining, Dil-oxLDL uptake and the BODIPY strategy. The mRNA and protein ranges have been measured by qPCR and Western blotting, respectively. Isolation of CD4+ T cells and monocytes was carried out with monoclonal antibodies conjugated with microbeads. Manipulation of protein expression was performed by both small interference RNA (siRNA) knockdown or CRISPR/Cas9 knockout. The expression of mitochondrial reactive oxygen species (mtROS) was decided by circulate cytometry and confocal microscopy.
Outcomes: IFN-α enhanced oxLDL-induced foam cell formation and Dil-oxLDL uptake by macrophages. Along with IFN-α, a number of triggers of atherosclerosis, together with thrombin and IFN-γ, can induce CMPK2 expression, which was elevated in CD4+ T cells and CD14+ monocytes remoted from SLE sufferers in comparison with these remoted from controls. The evaluation of mobile subfractions revealed that CMPK2 was current in each mitochondrial and cytosolic fractions. IFN-α-induced CMPK2 expression was inhibited by Janus kinase (JAK)half of and tyrosine kinase 2 (Tyk2) inhibitors. Each the knockdown and knockout of CMPK2 attenuated IFN-α-mediated foam cell formation, which concerned the discount of scavenger receptor class A (SR-A) expression. CMPK2 additionally regulated IFN-α-enhanced mtROS manufacturing and inflammasome activation.
Conclusions: The research means that CMPK2 performs contributing roles within the pro-atherogenic results of IFN-α.

ELISA kit for Human Tubulin beta-4 chain (TUBB4) |
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KTE60116-48T | Abbkine | 48T | EUR 398.4 |
Description: Quantitative sandwich ELISA for measuring Human Tubulin beta-4 chain (TUBB4) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human Tubulin beta-4 chain (TUBB4) |
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KTE60116-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2538 |
Description: Quantitative sandwich ELISA for measuring Human Tubulin beta-4 chain (TUBB4) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Human Tubulin beta-4 chain (TUBB4) |
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KTE60116-96T | Abbkine | 96T | EUR 646.8 |
Description: Quantitative sandwich ELISA for measuring Human Tubulin beta-4 chain (TUBB4) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
Beta Tubulin Antibody / TUBB1 |
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RQ5777 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: TUBB1 is a gene that codes for the protein Tubulin beta-1 chain in humans. This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y. |
Beta Tubulin Antibody / TUBB3 |
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V7658-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. |
Beta Tubulin Antibody / TUBB3 |
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V7658-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. |
Beta Tubulin Antibody / TUBB3 |
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V7658SAF-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. |
Beta Tubulin Antibody / TUBB3 |
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V7659-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. |
Beta Tubulin Antibody / TUBB3 |
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V7659-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. |
Beta Tubulin Antibody / TUBB3 |
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V7659SAF-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. |
Beta Tubulin Antibody / TUBB3 |
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V8309-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord. [UniProt] |
Beta Tubulin Antibody / TUBB3 |
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V8309-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord. [UniProt] |
Beta Tubulin Antibody / TUBB3 |
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V8309SAF-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord. [UniProt] |
beta I Tubulin (TUBB1) Antibody |
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20-abx219168 | Abbexa |
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Tubulin Beta 1 (TUBB1) Antibody |
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20-abx318661 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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20-abx134678 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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20-abx134679 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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20-abx134680 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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20-abx134681 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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20-abx134683 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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20-abx242446 | Abbexa |
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Tubulin Beta 1 (TUBB1) Antibody |
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abx224141-100ug | Abbexa | 100 ug | EUR 493.2 |
Tubulin Beta 3 (TUBB3) Antibody |
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20-abx110304 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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20-abx110305 | Abbexa |
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Tubulin Beta 1 (TUBB1) Antibody |
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20-abx110582 | Abbexa |
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Tubulin Beta 3 (TUBb3) Antibody |
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20-abx174960 | Abbexa |
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Tubulin Beta 1 (TUBb1) Antibody |
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20-abx178748 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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20-abx121803 | Abbexa |
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Tubulin, Beta 3 (TUBB3) Antibody |
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20-abx116351 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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abx332407-100ul | Abbexa | 100 ul | EUR 510 |
Tubulin Beta 3 (TUBB3) Antibody |
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20-abx330237 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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abx331438-100ul | Abbexa | 100 ul | EUR 510 |
Tubulin Beta 3 (TUBB3) Antibody |
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20-abx326995 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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20-abx326998 | Abbexa |
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Tubulin Beta 6 (TUBB6) Antibody |
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abx026508-400ul | Abbexa | 400 ul | EUR 627.6 |
Tubulin Beta 6 (TUBB6) Antibody |
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abx026508-80l | Abbexa | 80 µl | EUR 343.2 |
Tubulin Beta 3 (TUBB3) Antibody |
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abx032605-400ul | Abbexa | 400 ul | EUR 627.6 |
Tubulin Beta 3 (TUBB3) Antibody |
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abx032605-80l | Abbexa | 80 µl | EUR 343.2 |
Tubulin Beta 3 (TUBB3) Antibody |
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abx036052-100ug | Abbexa | 100 ug | EUR 469.2 |
Tubulin Beta 3 (TUBB3) Antibody |
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abx019140-100ug | Abbexa | 100 ug | EUR 410.4 |
Tubulin Beta 3 (TUBB3) Antibody |
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abx019141-100ug | Abbexa | 100 ug | EUR 410.4 |
Tubulin Beta 1 (TUBB1) Antibody |
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20-abx101412 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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20-abx101413 | Abbexa |
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Tubulin Beta 6 (TUBB6) Antibody |
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20-abx101414 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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abx127119-50ul | Abbexa | 50 ul | EUR 493.2 |
Tubulin Beta 1 (TUBB1) Antibody |
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20-abx129118 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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20-abx123449 | Abbexa |
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Tubulin Beta 6 (TUBB6) Antibody |
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abx340217-100ug | Abbexa | 100 ug | EUR 469.2 |
Tubulin Beta 3 (TUBB3) Antibody |
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abx431689-200ul | Abbexa | 200 ul | EUR 460.8 |
Tubulin Beta 1 (TUBB1) Antibody |
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20-abx005943 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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20-abx002044 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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abx012294-100ul | Abbexa | 100 ul | EUR 493.2 |
Tubulin Beta 1 (TUBB1) Antibody |
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abx145776-100ug | Abbexa | 100 ug | EUR 469.2 |
Tubulin Beta 6 (TUBB6) Antibody |
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20-abx302860 | Abbexa |
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Tubulin Beta 2B (TUBB2B) Antibody |
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20-abx137361 | Abbexa |
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Tubulin Beta 2A (TUBB2A) Antibody |
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20-abx246726 | Abbexa |
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Tubulin, Beta 2B (TUBB2B) Antibody |
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20-abx116350 | Abbexa |
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Tubulin Beta 2A (TUBB2A) Antibody |
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20-abx326997 | Abbexa |
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Tubulin Beta 2A (TUBB2A) Antibody |
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20-abx109386 | Abbexa |
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Tubulin Beta 2B (TUBB2B) Antibody |
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abx026514-400ul | Abbexa | 400 ul | EUR 627.6 |
Tubulin Beta 2B (TUBB2B) Antibody |
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abx026514-80l | Abbexa | 80 µl | EUR 343.2 |
Tubulin Beta 2A (TUBB2A) Antibody |
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abx027572-400ul | Abbexa | 400 ul | EUR 627.6 |
Tubulin Beta 2A (TUBB2A) Antibody |
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abx027572-80l | Abbexa | 80 µl | EUR 343.2 |
Tubulin Beta 2A (TUBB2A) Antibody |
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abx016016-100ug | Abbexa | 100 ug | EUR 493.2 |
Tubulin Beta 2B (TUBB2B) Antibody |
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abx145775-100ug | Abbexa | 100 ug | EUR 469.2 |
Tubulin Beta 2A (TUBB2A) Antibody |
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abx145790-100ug | Abbexa | 100 ug | EUR 469.2 |
beta IV Tubulin antibody |
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22498-100ul | SAB | 100ul | EUR 468 |
Beta Tubulin Antibody / TUBB |
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F54148-0.05ML | NSJ Bioreagents | 0.05 ml | EUR 140.25 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. |
Beta Tubulin Antibody / TUBB |
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F54148-0.2ML | NSJ Bioreagents | 0.2 ml | EUR 322.15 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. |
Beta Tubulin Antibody / TUBB |
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RQ5179 | NSJ Bioreagents | 100ul | EUR 356.15 |
Description: The TUBB gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [RefSeq] |
Beta Tubulin Antibody / TUBB |
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RQ6081 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: Tubulin beta chain is a protein that in humans is encoded by the TUBB gene. This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. |
Tubulin beta 1 Antibody (TUBB1) |
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F51482-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Tubulin beta-1 chain (TUBB1) is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. |
Tubulin beta 1 Antibody (TUBB1) |
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F40185-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Tubulin beta-1 chain is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y. |
Tubulin beta 1 Antibody (TUBB1) |
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F40189-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. |
TUBB6 Antibody (Tubulin beta 6) |
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F41790-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity). |
TUBB6 Antibody (Tubulin beta 6) |
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F41790-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity). |
Tubulin beta 8 Antibody (TUBB8) |
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F42844-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity). |
TUBB8 Antibody (Tubulin beta 8) |
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F42844-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity). |
Tubulin beta 3 Antibody (TUBB3) |
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F49314-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: Beta III tubulin is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development. As exemplified in cerebellar and sympathoadrenal neurogenesis, the distribution of beta III is neuron-associated, exhibiting distinct temporospatial gradients according to the regional neuroepithelia of origin. However, transient expression of this protein is also present in the subventricular zones of the CNS comprising putative neuronal- and/or glial precursor cells, as well as in Kulchitsky neuroendocrine cells of the fetal respiratory epithelium. This temporally restricted, potentially non-neuronal expression may have implications in the identification of presumptive neurons derived from embryonic stem cells. |
Tubulin beta 3 Antibody / TUBB3 |
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R32611 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: Tubulin beta-3 chain is a protein that in humans is encoded by the TUBB3 gene. This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. |
Tubulin Beta (TUBB) Antibody |
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abx246727-100ul | Abbexa | 100 ul | EUR 627.6 |
Tubulin Beta (TUBB) Antibody |
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abx246728-100ul | Abbexa | 100 ul | EUR 627.6 |
Tubulin Beta (TUBB) Antibody |
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abx246729-100ul | Abbexa | 100 ul | EUR 627.6 |
Tubulin Beta (TUBB) Antibody |
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abx246734-400ul | Abbexa | 400 ul | EUR 678 |
Tubulin Beta (TUBB) Antibody |
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abx246734-80l | Abbexa | 80 µl | EUR 360 |
Tubulin Beta (TUBB) Antibody |
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20-abx249495 | Abbexa |
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Tubulin Beta (TUBB) Antibody |
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abx230879-100ug | Abbexa | 100 ug | EUR 610.8 |
Tubulin Beta (TUBB) Antibody |
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abx230880-100ug | Abbexa | 100 ug | EUR 610.8 |
Tubulin Beta (TUBB) Antibody |
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abx219172-100ug | Abbexa | 100 ug | EUR 526.8 |
Tubulin Beta (TUBB) Antibody |
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20-abx110666 | Abbexa |
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Tubulin Beta (TUBB) Antibody |
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20-abx110667 | Abbexa |
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Tubulin Beta (TUBB) Antibody |
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abx139403-01mg | Abbexa | 0.1 mg | EUR 477.6 |
Tubulin Beta (TUBB) Antibody |
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20-abx132236 | Abbexa |
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Tubulin Beta (TUBB) Antibody |
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20-abx132255 | Abbexa |
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Tubulin Beta (TUBB) Antibody |
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20-abx132364 | Abbexa |
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Tubulin, Beta (TUBB) Antibody |
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20-abx116349 | Abbexa |
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Tubulin Beta (TUBB) Antibody |
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20-abx118008 | Abbexa |
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Tubulin Beta (TUBB) Antibody |
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20-abx121030 | Abbexa |
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Tubulin Beta (TUBB) Antibody |
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abx025155-400ul | Abbexa | 400 ul | EUR 627.6 |
Tubulin Beta (TUBB) Antibody |
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abx025155-80l | Abbexa | 80 µl | EUR 343.2 |
Tubulin Beta (TUBB) Antibody |
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abx018233-100ug | Abbexa | 100 ug | EUR 460.8 |
Tubulin Beta (TUBB) Antibody |
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abx018336-100ug | Abbexa | 100 ug | EUR 526.8 |
Tubulin Beta (TUBB) Antibody |
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abx019025-100ug | Abbexa | 100 ug | EUR 385.2 |
Tubulin Beta (TUBB) Antibody |
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20-abx019026 | Abbexa |
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Tubulin Beta (TUBB) Antibody |
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abx019185-100ug | Abbexa | 100 ug | EUR 410.4 |
Tubulin Beta (TUBB) Antibody |
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abx037893-100ug | Abbexa | 100 ug | EUR 469.2 |
Tubulin Beta (TUBB) Antibody |
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abx037894-100ug | Abbexa | 100 ug | EUR 469.2 |
Tubulin Beta (TUBB) Antibody |
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20-abx101054 | Abbexa |
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Tubulin Beta (TUBB) Antibody |
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20-abx124984 | Abbexa |
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Tubulin Beta (TUBB) Antibody |
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20-abx005574 | Abbexa |
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Tubulin Beta (TUBB) Antibody |
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abx012291-100ug | Abbexa | 100 ug | EUR 526.8 |
Tubulin Beta (TUBB) Antibody |
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20-abx013240 | Abbexa |
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Tubulin Beta (TUBB) Antibody |
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abx145777-100ug | Abbexa | 100 ug | EUR 469.2 |
beta 3-Tubulin (TUBB3) Antibody |
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20-abx134677 | Abbexa |
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beta 3-Tubulin (TUBB3) Antibody |
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20-abx134682 | Abbexa |
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beta 1-Tubulin (TUBB1) Antibody |
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20-abx134686 | Abbexa |
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beta 1-Tubulin (TUBB1) Antibody |
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20-abx134687 | Abbexa |
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Tubulin beta 4Q Antibody (TUBB4Q) |
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F52213-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity). |
TUBB4Q Antibody (Tubulin beta 4Q) |
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F52213-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity). |
Tubulin beta 2A Antibody / TUBB2A |
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F54147-0.05ML | NSJ Bioreagents | 0.05 ml | EUR 140.25 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). |
Tubulin beta 2A Antibody / TUBB2A |
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F54147-0.2ML | NSJ Bioreagents | 0.2 ml | EUR 322.15 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). |
TUBB8B Antibody (Tubulin beta 8B) |
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F41793-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. |
TUBB8B Antibody (Tubulin beta 8B) |
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F41793-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. |
TUBB2B Antibody (Tubulin beta 2B) |
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F41797-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq]. |
TUBB2B Antibody (Tubulin beta 2B) |
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F41797-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
Description: The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq]. |
Tubulin beta 2A Antibody (TUBB2A) |
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F43212-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity). |
TUBB2A Antibody (Tubulin beta 2A) |
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F43212-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity). |
Tubulin beta 2C Antibody (TUBB2C) |
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F49034-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
Description: TUBB2C is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. |
TUBB2C Antibody (Tubulin beta 2C) |
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F49034-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
Description: TUBB2C is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. |
Beta III Tubulin Antibody (TUBB3) |
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F49314-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
Description: Beta III tubulin is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development. As exemplified in cerebellar and sympathoadrenal neurogenesis, the distribution of beta III is neuron-associated, exhibiting distinct temporospatial gradients according to the regional neuroepithelia of origin. However, transient expression of this protein is also present in the subventricular zones of the CNS comprising putative neuronal- and/or glial precursor cells, as well as in Kulchitsky neuroendocrine cells of the fetal respiratory epithelium. This temporally restricted, potentially non-neuronal expression may have implications in the identification of presumptive neurons derived from embryonic stem cells. |
Tubulin Beta 6 (TUBB6) Antibody (HRP) |
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20-abx311512 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody (HRP) |
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20-abx108851 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody (HRP) |
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20-abx108852 | Abbexa |
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Tubulin Beta 1 (TUBB1) Antibody (HRP) |
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20-abx109143 | Abbexa |
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Tubulin Beta 1 (TUBB1) Antibody (HRP) |
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20-abx310961 | Abbexa |
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Tubulin Beta 6 (TUBB6) Antibody (FITC) |
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20-abx311513 | Abbexa |
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Tubulin Beta 3 (TUBb3) Antibody (FITC) |
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20-abx271228 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody (FITC) |
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20-abx107431 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody (FITC) |
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20-abx107432 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody Pair |
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abx117637-1pair5x96wellplates | Abbexa | 1 pair (5x96 well plates) | EUR 1212 |
Tubulin Beta 1 (TUBb1) Antibody Pair |
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20-abx370772 | Abbexa |
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Tubulin Beta 1 (TUBB1) Antibody (FITC) |
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20-abx107725 | Abbexa |
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Tubulin Beta 2A (TUBB2A) Antibody (HRP) |
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20-abx108850 | Abbexa |
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Tubulin Beta 1 (TUBB1) Antibody (FITC) |
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20-abx310962 | Abbexa |
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Tubulin Beta 2A (TUBB2A) Antibody (FITC) |
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20-abx107430 | Abbexa |
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Tubulin Beta 6 (TUBB6) Antibody (Biotin) |
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20-abx311514 | Abbexa |
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Tubulin Beta 3 (TUBb3) Antibody (Biotin) |
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20-abx271494 | Abbexa |
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Tubulin Beta 1 (TUBB1) Antibody (Biotin) |
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20-abx106312 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody (Biotin) |
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20-abx106017 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody (Biotin) |
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20-abx106018 | Abbexa |
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Tubulin Beta 6 (TUBb6) Antibody (Biotin) |
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20-abx274250 | Abbexa |
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Tubulin Beta 1 (TUBB1) Antibody (Biotin) |
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20-abx310963 | Abbexa |
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Tubulin Beta 2A (TUBB2A) Antibody (Biotin) |
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20-abx106016 | Abbexa |
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Tubulin Beta-8 Chain (TUBB8) Antibody |
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abx027305-400ul | Abbexa | 400 ul | EUR 627.6 |
Tubulin Beta-8 Chain (TUBB8) Antibody |
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abx027305-80l | Abbexa | 80 µl | EUR 343.2 |
Tubulin Beta-8 Chain (TUBB8) Antibody |
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20-abx006140 | Abbexa |
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Active Tubulin Beta (TUBb) |
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4-APB870Hu01 | Cloud-Clone |
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Description: Recombinant Human Tubulin Beta expressed in: E.coli |
Recombinant Tubulin Beta 1 (TUBb1) |
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4-RPE707Hu01 | Cloud-Clone |
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Description: Recombinant Human Tubulin Beta 1 expressed in: E.coli |
Recombinant Tubulin Beta 1 (TUBb1) |
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4-RPE707Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Tubulin Beta 1 expressed in: E.coli |
Recombinant Tubulin Beta 3 (TUBb3) |
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4-RPE711Hu01 | Cloud-Clone |
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Description: Recombinant Human Tubulin Beta 3 expressed in: E.coli |
Recombinant Tubulin Beta 6 (TUBb6) |
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4-RPE712Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Tubulin Beta 6 expressed in: E.coli |
Tubulin Beta (TUBB) Antibody (HRP) |
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20-abx134684 | Abbexa |
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Polyclonal TUBB / Beta Tubulin Antibody |
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APR13864G | Leading Biology | 0.05ml | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TUBB / Beta Tubulin . This antibody is tested and proven to work in the following applications: |
Monoclonal TUBB / Beta Tubulin Antibody |
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APR13865G | Leading Biology | 0.05ml | EUR 580.8 |
Description: A Monoclonal antibody against Human TUBB / Beta Tubulin. The antibodies are raised in Mouse. This antibody is applicable in WB and IHC-P, IF |
Tubulin Beta-2C Chain (TUBB2C) Antibody |
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abx032420-400ul | Abbexa | 400 ul | EUR 627.6 |
Tubulin Beta-2C Chain (TUBB2C) Antibody |
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abx032420-80l | Abbexa | 80 µl | EUR 343.2 |
Tubulin Beta-4B Chain (TUBB4B) Antibody |
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20-abx125403 | Abbexa |
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Tubulin Beta-2C Chain (TUBB2C) Antibody |
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abx340218-100ug | Abbexa | 100 ug | EUR 469.2 |
Tubulin Beta-4A Chain (TUBB4A) Antibody |
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20-abx302623 | Abbexa |
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Tubulin Beta (TUBB) CLIA Kit |
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20-abx493193 | Abbexa |
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Mouse Tubulin Beta 1 (TUBB1) Protein |
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20-abx069519 | Abbexa |
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Human Tubulin Beta 3 (TUBB3) Protein |
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20-abx069520 | Abbexa |
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Mouse Tubulin Beta 6 (TUBB6) Protein |
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20-abx069521 | Abbexa |
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Human Tubulin Beta 1 (TUBB1) Protein |
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20-abx166510 | Abbexa |
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Human Tubulin beta-3 chain (TUBB3) |
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1-CSB-RP038744h | Cusabio |
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Description: Recombinant Human Tubulin beta-3 chain(TUBB3),partial expressed in E.coli |
Human Tubulin beta-6 chain (TUBB6) |
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1-CSB-EP880105HU | Cusabio |
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Description: Recombinant Human Tubulin beta-6 chain(TUBB6) expressed in E.coli |
Rabbit Anti-Human tubulin, beta 1 (TUBB1) IgG (aff pure) |
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AB-23096-A | Alpha Diagnostics | 100ug | EUR 578.4 |
Mouse Monoclonal Anti-Human Tubulin, beta 3 (TUBB3) IgG |
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MA-20374 | Alpha Diagnostics | 100 ul | EUR 518.4 |
Tubulin Beta (TUBB) ELISA Kit |
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20-abx156857 | Abbexa |
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Tubulin Beta 1 Class VI (TUBB1) Antibody |
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20-abx159741 | Abbexa |
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Tubulin Beta 1 Class VI (TUBB1) Antibody |
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20-abx159742 | Abbexa |
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Tubulin Beta 1 Class VI (TUBB1) Antibody |
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abx159743-100ul | Abbexa | 100 ul | EUR 427.2 |
Tubulin Beta 1 Class VI (TUBB1) Antibody |
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abx159744-100ul | Abbexa | 100 ul | EUR 427.2 |
Cow Tubulin Beta 3 (TUBB3) ELISA Kit |
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abx518029-96tests | Abbexa | 96 tests | EUR 1093.2 |
Rat Tubulin Beta 3 (TUBB3) ELISA Kit |
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abx518032-96tests | Abbexa | 96 tests | EUR 801.6 |
Pig Tubulin Beta 5 (TUBB5) ELISA Kit |
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abx518666-96tests | Abbexa | 96 tests | EUR 1093.2 |
Rat Tubulin Beta 3 (TUBb3) ELISA Kit |
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RDR-TUBb3-Ra-48T | Reddot Biotech | 48T | EUR 512 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Rat Tubulin Beta 3 (TUBb3) ELISA Kit |
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RDR-TUBb3-Ra-96T | Reddot Biotech | 96T | EUR 731.5 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Rat Tubulin Beta 3 (TUBb3) ELISA Kit |
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RD-TUBb3-Ra-48T | Reddot Biotech | 48T | EUR 487.7 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Rat Tubulin Beta 3 (TUBb3) ELISA Kit |
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RD-TUBb3-Ra-96T | Reddot Biotech | 96T | EUR 696.7 |
Description: tissue homogenates, cell lysates and other biological fluids. |
Recombinant Tubulin Beta (TUBb) |
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4-RPB870Hu01 | Cloud-Clone |
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Description: Recombinant Human Tubulin Beta expressed in: E.coli |
Mouse Tubulin Beta 1 (TUBB1) CLIA Kit |
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20-abx494707 | Abbexa |
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Human Tubulin Beta 3 (TUBB3) CLIA Kit |
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20-abx494708 | Abbexa |
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Human Tubulin Beta 1 (TUBB1) CLIA Kit |
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20-abx496423 | Abbexa |
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Human Tubulin beta-2A chain (TUBB2A) |
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1-CSB-YP025320HU | Cusabio |
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Description: Recombinant Human Tubulin beta-2A chain(TUBB2A) expressed in Yeast |
Ocena odpowiedzi immunogennej na nowatorską szczepionkę z koniugatem enterobaktyny u kurcząt do produkcji przeciwciał żółtka jaja specyficznych dla enterobaktyny
- Passive immunization with particular egg yolk antibodies (immunoglobulin Y, IgY) is rising as a promising various to antibiotics to manage bacterial infections. Lately, we developed a novel conjugate vaccine that might set off a robust immune response in rabbits directed towards enterobactin (Ent), a extremely conserved siderophore molecule utilized by completely different Gram-negative pathogens. Nevertheless, induction of Ent-specific antibodies seemed to be affected by the selection of animal host and vaccination routine.
- It’s nonetheless unknown if the Ent conjugate vaccine can set off a selected immune response in layers for the aim of manufacturing of anti-Ent egg yolk IgY. On this research, three hen vaccination trials with completely different regimens have been carried out to find out circumstances for environment friendly manufacturing of anti-Ent egg yolk IgY. Purified Ent was conjugated to 3 provider proteins, keyhole limpet hemocyanin (KLH), bovine serum albumin (BSA) and CmeC (a subunit vaccine candidate), respectively.
- Intramuscular immunization of Barred Rock layers with KLH-Ent conjugate 4 instances induced sturdy immune response towards entire conjugate vaccine however the titer of Ent-specific IgY didn’t change in yolk with solely a four fold improve detected in serum. Within the second trial, three completely different Ent conjugate vaccines have been evaluated in Rhode Island Crimson pullets with 4 subcutaneous injections. The KLH-Ent or CmeC-Ent conjugate persistently induced excessive degree of Ent-specific IgY in each serum (as much as 2,048 fold) and yolk (as much as 1,024 fold) in every particular person hen. Nevertheless, the Ent-specific immune response was solely quickly and reasonably induced utilizing a BSA-Ent vaccination.
- Within the third trial, ten White Leghorn layers have been subcutaneously immunized thrice with KLH-Ent, resulting in constant and robust immune response towards each entire conjugate and the Ent molecule in every hen; the imply titer of Ent-specific IgY elevated roughly 32 and 256 fold in serum and yolk, respectively. According to its potent binding to numerous Ent derivatives, the Ent-specific egg yolk IgY additionally inhibited in vitro progress of a consultant Escherichia coli pressure.
- Collectively, this research demonstrated that the novel Ent conjugate vaccine might induce sturdy, particular, and sturdy immune response in chickens. The Ent-specific hyperimmune egg yolk IgY has potential for passive immune intervention towards Gram-negative infections.
Korelacja odpowiedzi na szczepionki
Introduction: The humoral response to vaccinations varies extensively between people. There isn’t a information obtainable on the correlation between responses to completely different vaccines. On this research, we investigated the correlation of antibody responses between routine vaccine antigens in infants.
Strategies: One and 7 months after the 6-month vaccinations and one month after the 12-month vaccinations, antibody concentrations to diphtheria, tetanus, pertussis, polio (serotypes 1-3), Haemophilus influenzae sort b (Hib), pneumococcus (13 serotypes), meningococcus C, measles, mumps and rubella have been measured utilizing fluorescent bead-based multiplex immune-assays. For the correlation of antibody responses, Spearman’s rank correlation coefficients (ρ) with 95% confidence intervals (CI) have been calculated between responses to every vaccine antigen.
Outcomes: The correlation between concentrations of antibodies to the vaccinations ending at 6 months of age was greater one month in comparison with seven months after vaccination. The strongest correlations at each time factors have been noticed between antibody responses to completely different polio serotypes, sure pneumococcal serotypes and between responses to diphtheria and pneumococcal (conjugated to a diphtheria toxoid) vaccine antigens. Correlation between responses to tetanus, Hib, pertussis, polio and different vaccine antigens have been weak. The correlation between antibody responses to the 12-month vaccine antigens was weaker than to the 6-month vaccine antigens and there was a adverse correlation between responses to measles, mumps, rubella vaccine and non-live vaccine antigens (meningococcus C, tetanus and Hib). There was solely weak correlation between antibody responses to vaccines of the identical sort (e.g. conjugated polysaccharide or toxoid vaccines).
Conclusion: Correlation between antibody responses to related antigens in the identical vaccine (equivalent to completely different serotypes of a micro organism or virus), in addition to responses to antigens conjugated to related provider proteins, are sturdy. In distinction, correlation between responses to different vaccines are weak. Measuring antibody responses to at least one or a number of vaccine antigens subsequently doesn’t supply a dependable surrogate marker of responses to unrelated vaccines.
Nowatorski automatyczny check immunologiczny dla przeciwciał NY-ESO-1 i XAGE1 w surowicy w skojarzonym przewidywaniu odpowiedzi na terapię przeciw zaprogramowanej śmierci komórkowej – 1 w niedrobnokomórkowym raku płuca
Background: Anti-programmed cell death-1 (PD-1) antibodies (Abs) are key medication in non-small-cell lung most cancers (NSCLC) remedy; nonetheless, medical advantages with anti-PD-1 monotherapy are restricted. We reported that serum Abs towards cancer-testis antigens NY-ESO-1 and XAGE1 predicted medical advantages. We aimed to develop a totally automated immunoassay system measuring NY-ESO-1/XAGE1 Abs.
Strategies: Sera from 30 NSCLC sufferers earlier than anti-PD-1 monotherapy have been reacted with recombinant NY-ESO-1 protein- or artificial XAGE1 peptide-coated magnetic beads. ALP-conjugated Ab and chemiluminescent substrate have been added and luminescence measured. These procedures have been automated utilizing excessive sensitivity chemiluminescent enzyme immunoassay (HISCLTM). NY-ESO-1/XAGE1 Ab stability was examined beneath numerous circumstances. Response prediction accuracy was evaluated utilizing space beneath receiver working curve (AUROC).
Outcomes: HISCL detected particular serum NY-ESO-1/XAGE1 Abs, which ranges in ELISA and HISCL have been extremely correlated. The Ab ranges in HISCL have been secure at 4 temperatures, 5 freeze/thaw cycles, and long-term storage; the degrees weren’t interfered by frequent blood elements. The Ab ranges in 15 NSCLC responders to anti-PD-1 monotherapy have been considerably greater than these in non-responders and wholesome donors. The AUROC was the best (0.91; 95% CI, 0.78-1.0) in combinatory prediction with NY-ESO-1/XAGE1 Abs.
Conclusion: Our immunoassay system is beneficial to foretell medical advantages with NSCLC immune-checkpoint remedy.