Białko mitochondrialne CMPK2 reguluje tworzenie
Białko mitochondrialne CMPK2 reguluje tworzenie komórek piankowatych wzmocnionych przez IFN alfa, potencjalnie przyczyniając się do przedwczesnej miażdżycy tętnic w SLE
Background: Untimely atherosclerosis happens in sufferers with SLE; nonetheless, the mechanisms stay unclear. Each mitochondrial equipment and proinflammatory cytokine interferon alpha (IFN-α) probably contribute to atherogenic processes in SLE. Right here, we discover the roles of the mitochondrial protein cytidine/uridine monophosphate kinase 2 (CMPK2) in IFN-α-mediated pro-atherogenic occasions.
Strategies: Foam cell measurements have been carried out by oil purple O staining, Dil-oxLDL uptake and the BODIPY strategy. The mRNA and protein ranges have been measured by qPCR and Western blotting, respectively. Isolation of CD4+ T cells and monocytes was carried out with monoclonal antibodies conjugated with microbeads. Manipulation of protein expression was performed by both small interference RNA (siRNA) knockdown or CRISPR/Cas9 knockout. The expression of mitochondrial reactive oxygen species (mtROS) was decided by circulate cytometry and confocal microscopy.
Outcomes: IFN-α enhanced oxLDL-induced foam cell formation and Dil-oxLDL uptake by macrophages. Along with IFN-α, a number of triggers of atherosclerosis, together with thrombin and IFN-γ, can induce CMPK2 expression, which was elevated in CD4+ T cells and CD14+ monocytes remoted from SLE sufferers in comparison with these remoted from controls. The evaluation of mobile subfractions revealed that CMPK2 was current in each mitochondrial and cytosolic fractions. IFN-α-induced CMPK2 expression was inhibited by Janus kinase (JAK)half of and tyrosine kinase 2 (Tyk2) inhibitors. Each the knockdown and knockout of CMPK2 attenuated IFN-α-mediated foam cell formation, which concerned the discount of scavenger receptor class A (SR-A) expression. CMPK2 additionally regulated IFN-α-enhanced mtROS manufacturing and inflammasome activation.
Conclusions: The research means that CMPK2 performs contributing roles within the pro-atherogenic results of IFN-α.
Tubulin Beta-4A Chain (TUBB4) Antibody |
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| abx145781-96tests | Abbexa | 96 tests | EUR 337.5 |
Tubulin Beta-4A Chain (TUBB4) Antibody |
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Tubulin Beta-4A Chain (TUBB4) Antibody |
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Tubulin Beta-4A Chain (TUBB4) Antibody |
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| abx145784-96tests | Abbexa | 96 tests | EUR 337.5 |
TUBB4 (beta IV Tubulin) mouse monoclonal antibody, clone OTI3F1 (formerly 3F1) |
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TUBB4 (beta IV Tubulin) mouse monoclonal antibody, clone OTI3F1 (formerly 3F1) |
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TUBB4 (beta IV Tubulin) mouse monoclonal antibody, clone OTI6C2 (formerly 6C2) |
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TUBB4 (beta IV Tubulin) mouse monoclonal antibody, clone OTI6C2 (formerly 6C2) |
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TUBB4 (beta IV Tubulin) mouse monoclonal antibody, clone OTI8E3 (formerly 8E3) |
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TUBB4 (beta IV Tubulin) mouse monoclonal antibody, clone OTI8E3 (formerly 8E3) |
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TUBB4 (beta IV Tubulin) mouse monoclonal antibody, clone OTI6E3 (formerly 6E3) |
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TUBB4 (beta IV Tubulin) mouse monoclonal antibody, clone OTI6E3 (formerly 6E3) |
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TUBB4 (beta IV Tubulin) mouse monoclonal antibody, clone OTI3C12 (formerly 3C12) |
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TUBB4 (beta IV Tubulin) mouse monoclonal antibody, clone OTI3C12 (formerly 3C12) |
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TUBB4A (untagged)-Human tubulin, beta 4 (TUBB4) |
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TUBB4A (untagged)-Human tubulin, beta 4 (TUBB4) |
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Human Tubulin Beta 4(TUBb4)ELISA Kit |
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Tubb4a (GFP-tagged) - Mouse tubulin, beta 4 (Tubb4) |
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TUBB4A (GFP-tagged) - Human tubulin, beta 4 (TUBB4) |
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Tubb4a (untagged) - Mouse tubulin, beta 4 (Tubb4), (10ug) |
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| MC202698 | Origene Technologies GmbH | 10 µg | Ask for price |
Human Tubulin beta-4 chain (TUBB4) ELISA Kit |
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| EK5969 | SAB | 96Т | EUR 799 |
Human Tubulin beta-4 chain (TUBB4) ELISA Kit |
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| AE12787HU-48Tests | Abebio | 48 Tests | EUR 325 |
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Description: Human (Homo sapiens) |
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Human Tubulin beta-4 chain (TUBB4) ELISA Kit |
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| AE12787HU-96Tests | Abebio | 96 Tests | EUR 610 |
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Description: Human (Homo sapiens) |
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Human Tubulin beta-4 chain (TUBB4) ELISA Kit |
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| KTE60116-48T | Abbkine | 48T | EUR 339 |
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Description: This Human Tubulin beta-4 chain (TUBB4) ELISA Kit employs a two-site sandwich ELISA to quantitate TUBB4. |
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Human Tubulin beta-4 chain (TUBB4) ELISA Kit |
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| KTE60116-96T | Abbkine | 96T | EUR 589 |
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Description: This Human Tubulin beta-4 chain (TUBB4) ELISA Kit employs a two-site sandwich ELISA to quantitate TUBB4. |
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Human Tubulin beta-4 chain (TUBB4) ELISA Kit |
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| KTE60116-96T5 | Abbkine | 96 T×5 | EUR 2629 |
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Description: This Human Tubulin beta-4 chain (TUBB4) ELISA Kit employs a two-site sandwich ELISA to quantitate TUBB4. |
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Human Tubulin beta-4 chain (TUBB4) ELISA Kit |
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| KTE60116-96T50 | Abbkine | 96 T×50 | EUR 24569 |
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Description: This Human Tubulin beta-4 chain (TUBB4) ELISA Kit employs a two-site sandwich ELISA to quantitate TUBB4. |
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Human Tubulin beta- 4 chain, TUBB4 ELISA KIT |
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| ELI-13731h | Lifescience Market | 96 Tests | EUR 988.8 |
Mouse Tubulin beta- 4 chain, Tubb4 ELISA KIT |
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| ELI-53137m | Lifescience Market | 96 Tests | EUR 1038 |
Tubb4a (Myc-DDK-tagged) - Mouse tubulin, beta 4 (Tubb4) |
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| MR207086 | Origene Technologies GmbH | 10 µg | Ask for price |
TUBB4A (Myc-DDK-tagged)-Human tubulin, beta 4 (TUBB4) |
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| RC203945 | Origene Technologies GmbH | 10 µg | Ask for price |
Bovine Tubulin beta- 4 chain, TUBB4 ELISA KIT |
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| ELI-29137b | Lifescience Market | 96 Tests | EUR 1113.6 |
Tubb4a (untagged ORF) - Rat tubulin, beta 4 (Tubb4), (10 ug) |
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ELISA kit for Human Tubulin beta-4 chain (TUBB4) |
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| KTE60116-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2538 |
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Description: Quantitative sandwich ELISA for measuring Human Tubulin beta-4 chain (TUBB4) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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Tubb4a (Myc-DDK-tagged ORF) - Rat tubulin, beta 4 (Tubb4), (10 ug) |
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Lenti ORF clone of Human tubulin, beta 4 (TUBB4), mGFP tagged |
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Lenti ORF clone of Human tubulin, beta 4 (TUBB4), mGFP tagged |
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Lenti ORF clone of Tubb4a (mGFP-tagged) - Mouse tubulin, beta 4 (Tubb4) |
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Lenti ORF clone of Tubb4a (Myc-DDK-tagged) - Mouse tubulin, beta 4 (Tubb4) |
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Lenti ORF clone of Human tubulin, beta 4 (TUBB4), Myc-DDK-tagged |
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Lenti ORF clone of Human tubulin, beta 4 (TUBB4), Myc-DDK-tagged |
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3`UTR clone of tubulin beta 4 (TUBB4) for miRNA target validation |
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Beta Tubulin Antibody / TUBB1 |
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| RQ5777 | NSJ Bioreagents | 100 ug | EUR 356.15 |
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Description: TUBB1 is a gene that codes for the protein Tubulin beta-1 chain in humans. This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y. |
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Beta Tubulin Antibody / TUBB3 |
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| V8309-100UG | NSJ Bioreagents | 100 ug | EUR 424.15 |
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Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord. [UniProt] |
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Beta Tubulin Antibody / TUBB3 |
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| V8309-20UG | NSJ Bioreagents | 20 ug | EUR 186.15 |
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Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord. [UniProt] |
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Beta Tubulin Antibody / TUBB3 |
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| V8309SAF-100UG | NSJ Bioreagents | 100 ug | EUR 424.15 |
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Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord. [UniProt] |
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Beta Tubulin Antibody / TUBB3 |
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| V7658-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
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Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. |
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Beta Tubulin Antibody / TUBB3 |
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| V7658-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
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Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. |
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Beta Tubulin Antibody / TUBB3 |
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| V7658SAF-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
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Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. |
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Beta Tubulin Antibody / TUBB3 |
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| V7659-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
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Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. |
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Beta Tubulin Antibody / TUBB3 |
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| V7659-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
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Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. |
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Beta Tubulin Antibody / TUBB3 |
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| V7659SAF-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
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Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. |
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Lenti ORF clone of Tubb4a (mGFP-tagged ORF) - Rat tubulin, beta 4 (Tubb4), (10 ug) |
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| RR203612L4 | Origene Technologies GmbH | 10 µg | Ask for price |
beta I Tubulin (TUBB1) Antibody |
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| 20-abx219168 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| 20-abx110304 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| 20-abx110305 | Abbexa |
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Tubulin Beta 1 (TUBB1) Antibody |
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| 20-abx110582 | Abbexa |
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Tubulin Beta 1 (TUBB1) Antibody |
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| 20-abx101412 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| 20-abx101413 | Abbexa |
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Tubulin Beta 6 (TUBB6) Antibody |
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| 20-abx101414 | Abbexa |
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Tubulin Beta 1 (TUBB1) Antibody |
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| 20-abx129118 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| 20-abx121803 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| 20-abx123449 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| abx127119-50ul | Abbexa | 50 ul | EUR 493.2 |
Tubulin Beta 1 (TUBB1) Antibody |
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| abx145776-100ug | Abbexa | 100 ug | EUR 469.2 |
Tubulin Beta 3 (TUBB3) Antibody |
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| 20-abx134678 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| 20-abx134679 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| 20-abx134680 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| 20-abx134681 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| 20-abx134683 | Abbexa |
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Tubulin, Beta 3 (TUBB3) Antibody |
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| 20-abx116351 | Abbexa |
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Tubulin Beta 1 (TUBB1) Antibody |
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| 20-abx005943 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| abx036052-100ug | Abbexa | 100 ug | EUR 469.2 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx032605-400ul | Abbexa | 400 ul | EUR 627.6 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx032605-80l | Abbexa | 80 µl | EUR 343.2 |
Tubulin Beta 3 (TUBB3) Antibody |
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Tubulin Beta 3 (TUBB3) Antibody |
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| abx019141-100ug | Abbexa | 100 ug | EUR 410.4 |
Tubulin Beta 6 (TUBB6) Antibody |
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Tubulin Beta 6 (TUBB6) Antibody |
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Tubulin Beta 3 (TUBB3) Antibody |
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Tubulin Beta 3 (TUBB3) Antibody |
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| 20-abx002044 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| 20-abx242446 | Abbexa |
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Tubulin Beta 3 (TUBb3) Antibody |
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| 20-abx174960 | Abbexa |
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Tubulin Beta 1 (TUBB1) Antibody |
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| abx224141-100ug | Abbexa | 100 ug | EUR 493.2 |
Tubulin Beta 1 (TUBb1) Antibody |
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| 20-abx178748 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| abx332407-100ul | Abbexa | 100 ul | EUR 510 |
Tubulin Beta 3 (TUBB3) Antibody |
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| 20-abx326995 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| 20-abx326998 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| 20-abx330237 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| abx331438-100ul | Abbexa | 100 ul | EUR 510 |
Tubulin Beta 6 (TUBB6) Antibody |
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| 20-abx302860 | Abbexa |
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Tubulin Beta 3 (TUBB3) Antibody |
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| 20-abx318661 | Abbexa |
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Tubulin Beta 6 (TUBB6) Antibody |
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Tubulin Beta 3 (TUBB3) Antibody |
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| abx011148-100g | Abbexa | 100 µg | Ask for price |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx011148-10g | Abbexa | 10 µg | EUR 350 |
Tubulin Beta 3 (TUBB3) Antibody |
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Tubulin Beta 3 (TUBB3) Antibody |
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| abx012294-100g | Abbexa | 100 µg | Ask for price |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx012294-10g | Abbexa | 10 µg | EUR 362.5 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx012294-200g | Abbexa | 200 µg | Ask for price |
Tubulin Beta 1 (TUBB1) Antibody |
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| abx005943-100l | Abbexa | 100 µl | EUR 275 |
Tubulin Beta 1 (TUBB1) Antibody |
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| abx005943-50l | Abbexa | 50 µl | EUR 175 |
Tubulin Beta 1 (TUBB1) Antibody |
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| abx101412-100l | Abbexa | 100 µl | EUR 275 |
Tubulin Beta 1 (TUBB1) Antibody |
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| abx101412-1ml | Abbexa | 1 ml | EUR 775 |
Tubulin Beta 1 (TUBB1) Antibody |
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| abx101412-200l | Abbexa | 200 µl | EUR 350 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx101413-100l | Abbexa | 100 µl | EUR 275 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx101413-1ml | Abbexa | 1 ml | EUR 750 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx101413-200l | Abbexa | 200 µl | EUR 337.5 |
Tubulin Beta 6 (TUBB6) Antibody |
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| abx101414-100l | Abbexa | 100 µl | EUR 275 |
Tubulin Beta 6 (TUBB6) Antibody |
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| abx101414-1ml | Abbexa | 1 ml | EUR 775 |
Tubulin Beta 6 (TUBB6) Antibody |
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| abx101414-200l | Abbexa | 200 µl | EUR 350 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx127119-100l | Abbexa | 100 µl | EUR 175 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx127119-1ml | Abbexa | 1 ml | EUR 600 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx127119-200l | Abbexa | 200 µl | EUR 325 |
Tubulin Beta 2 (TUBB2) Antibody |
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| abx159753-100g | Abbexa | 100 µg | Ask for price |
Tubulin Beta 2 (TUBB2) Antibody |
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| abx159753-10g | Abbexa | 10 µg | EUR 325 |
Tubulin Beta 2 (TUBB2) Antibody |
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| abx159753-50g | Abbexa | 50 µg | Ask for price |
Tubulin, Beta 3 (TUBB3) Antibody |
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| abx116351-100g | Abbexa | 100 µg | EUR 612.5 |
Tubulin Beta 1 (TUBB1) Antibody |
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| abx129118-100l | Abbexa | 100 µl | EUR 275 |
Tubulin Beta 1 (TUBB1) Antibody |
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| abx129118-1ml | Abbexa | 1 ml | EUR 750 |
Tubulin Beta 1 (TUBB1) Antibody |
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| abx129118-200l | Abbexa | 200 µl | EUR 337.5 |
Tubulin Beta 3 (TUBb3) Antibody |
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| abx174960-100g | Abbexa | 100 g | Ask for price |
Tubulin Beta 3 (TUBb3) Antibody |
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| abx174960-25g | Abbexa | 25 g | EUR 787.5 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx123449-100l | Abbexa | 100 µl | EUR 175 |
Tubulin Beta 3 (TUBB3) Antibody |
|||
| abx123449-1ml | Abbexa | 1 ml | EUR 462.5 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx123449-200l | Abbexa | 200 µl | EUR 325 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx110304-100l | Abbexa | 100 µl | EUR 162.5 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx110305-100l | Abbexa | 100 µl | EUR 162.5 |
Tubulin Beta 1 (TUBB1) Antibody |
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| abx110582-100l | Abbexa | 100 µl | EUR 162.5 |
Tubulin Beta 6 (TUBB6) Antibody |
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| abx302860-100g | Abbexa | 100 µg | EUR 362.5 |
Tubulin Beta 6 (TUBB6) Antibody |
|||
| abx302860-20g | Abbexa | 20 µg | EUR 162.5 |
Tubulin Beta 6 (TUBB6) Antibody |
|||
| abx302860-50g | Abbexa | 50 µg | EUR 250 |
Tubulin Beta 3 (TUBB3) Antibody |
|||
| abx032605-400l | Abbexa | 400 µl | EUR 518.75 |
Tubulin Beta 3 (TUBB3) Antibody |
|||
| abx036052-100g | Abbexa | 100 µg | EUR 337.5 |
Tubulin Beta 6 (TUBB6) Antibody |
|||
| abx026508-400l | Abbexa | 400 µl | EUR 518.75 |
Tubulin Beta 3 (TUBB3) Antibody |
|||
| abx019140-400l | Abbexa | 400 µl | Ask for price |
Tubulin Beta 3 (TUBB3) Antibody |
|||
| abx019140-80l | Abbexa | 80 µl | EUR 300 |
Tubulin Beta 3 (TUBB3) Antibody |
|||
| abx019141-400l | Abbexa | 400 µl | Ask for price |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx019141-80l | Abbexa | 80 µl | EUR 300 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx242446-96tests | Abbexa | 96 tests | EUR 250 |
Tubulin Beta 1 (TUBB1) Antibody |
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| abx145776-1096tests | Abbexa | 10 × 96 tests | Ask for price |
Tubulin Beta 1 (TUBB1) Antibody |
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| abx145776-596tests | Abbexa | 5 × 96 tests | Ask for price |
Tubulin Beta 1 (TUBB1) Antibody |
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| abx145776-96tests | Abbexa | 96 tests | EUR 337.5 |
Tubulin Beta 1 (TUBB1) Antibody |
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| abx224141-100g | Abbexa | 100 µg | EUR 362.5 |
Tubulin Beta 1 (TUBb1) Antibody |
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| abx178748-96tests | Abbexa | 96 tests | EUR 275 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx431689-200l | Abbexa | 200 µl | EUR 387.5 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx326995-100g | Abbexa | 100 µg | EUR 250 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx326995-50g | Abbexa | 50 µg | EUR 187.5 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx326998-100g | Abbexa | 100 µg | EUR 250 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx326998-50g | Abbexa | 50 µg | EUR 187.5 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx330237-100g | Abbexa | 100 µg | Ask for price |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx330237-20g | Abbexa | 20 µg | EUR 187.5 |
Tubulin Beta 3 (TUBB3) Antibody |
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| abx330237-50g | Abbexa | 50 µg | EUR 250 |
Tubulin Beta 6 (TUBB6) Antibody |
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| abx340217-10mg | Abbexa | 10 mg | Ask for price |
Tubulin Beta 6 (TUBB6) Antibody |
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| abx340217-1mg | Abbexa | 1 mg | EUR 337.5 |
Tubulin Beta 1 (TUBB1) Antibody |
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| abx318661-100l | Abbexa | 100 µl | EUR 250 |
Tubulin Beta 1 (TUBB1) Antibody |
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| abx318661-50l | Abbexa | 50 µl | EUR 162.5 |
Tubulin Beta 2A (TUBB2A) Antibody |
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| 20-abx109386 | Abbexa |
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Tubulin Beta 2B (TUBB2B) Antibody |
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| abx145775-100ug | Abbexa | 100 ug | EUR 469.2 |
Tubulin Beta 2A (TUBB2A) Antibody |
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| abx145790-100ug | Abbexa | 100 ug | EUR 469.2 |
Tubulin, Beta 2B (TUBB2B) Antibody |
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| 20-abx116350 | Abbexa |
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Tubulin Beta 2B (TUBB2B) Antibody |
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| 20-abx137361 | Abbexa |
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Tubulin Beta 2A (TUBB2A) Antibody |
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| abx016016-100ug | Abbexa | 100 ug | EUR 493.2 |
Tubulin Beta 2B (TUBB2B) Antibody |
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| abx026514-400ul | Abbexa | 400 ul | EUR 627.6 |
Tubulin Beta 2B (TUBB2B) Antibody |
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| abx026514-80l | Abbexa | 80 µl | EUR 343.2 |
Tubulin Beta 2A (TUBB2A) Antibody |
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| abx027572-400ul | Abbexa | 400 ul | EUR 627.6 |
Tubulin Beta 2A (TUBB2A) Antibody |
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| abx027572-80l | Abbexa | 80 µl | EUR 343.2 |
Tubulin Beta 2A (TUBB2A) Antibody |
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| 20-abx246726 | Abbexa |
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Tubulin Beta 2A (TUBB2A) Antibody |
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| 20-abx326997 | Abbexa |
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Tubulin Beta 2A (TUBB2A) Antibody |
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| abx109386-100l | Abbexa | 100 µl | EUR 162.5 |
Tubulin, Beta 2B (TUBB2B) Antibody |
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| abx116350-50l | Abbexa | 50 µl | EUR 612.5 |
Tubulin Beta 2B (TUBB2B) Antibody |
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| abx026514-400l | Abbexa | 400 µl | EUR 518.75 |
Tubulin Beta 2A (TUBB2A) Antibody |
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| abx027572-400l | Abbexa | 400 µl | EUR 518.75 |
Tubulin Beta 2A (TUBB2A) Antibody |
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| abx016016-100g | Abbexa | 100 µg | EUR 362.5 |
Tubulin Beta 2A (TUBB2A) Antibody |
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| abx246726-1096tests | Abbexa | 10 × 96 tests | Ask for price |
Tubulin Beta 2A (TUBB2A) Antibody |
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| abx246726-596tests | Abbexa | 5 × 96 tests | EUR 518.75 |
Tubulin Beta 2A (TUBB2A) Antibody |
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| abx246726-96tests | Abbexa | 96 tests | EUR 281.25 |
Tubulin Beta 2B (TUBB2B) Antibody |
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| abx137361-100tests | Abbexa | 100 tests | EUR 225 |
Tubulin Beta 2B (TUBB2B) Antibody |
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| abx145775-1096tests | Abbexa | 10 × 96 tests | Ask for price |
Tubulin Beta 2B (TUBB2B) Antibody |
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| abx145775-596tests | Abbexa | 5 × 96 tests | Ask for price |
Tubulin Beta 2B (TUBB2B) Antibody |
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| abx145775-96tests | Abbexa | 96 tests | EUR 337.5 |
Tubulin Beta 2A (TUBB2A) Antibody |
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| abx145790-1096tests | Abbexa | 10 × 96 tests | Ask for price |
Tubulin Beta 2A (TUBB2A) Antibody |
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| abx145790-596tests | Abbexa | 5 × 96 tests | Ask for price |
Tubulin Beta 2A (TUBB2A) Antibody |
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| abx145790-96tests | Abbexa | 96 tests | EUR 337.5 |
Tubulin Beta 2A (TUBB2A) Antibody |
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| abx326997-100g | Abbexa | 100 µg | EUR 250 |
Tubulin Beta 2A (TUBB2A) Antibody |
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| abx326997-50g | Abbexa | 50 µg | EUR 187.5 |
beta IV Tubulin antibody |
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| 22498 | SAB | 100ul | EUR 479 |
beta IV Tubulin antibody |
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| 22498-100ul | SAB | 100ul | EUR 468 |
Lenti ORF clone of Tubb4a (Myc-DDK-tagged ORF) - Rat tubulin, beta 4 (Tubb4), (10 ug) |
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| RR203612L3 | Origene Technologies GmbH | 10 µg | Ask for price |
TUBB6 Antibody (Tubulin beta 6) |
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| F41790-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
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Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity). |
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TUBB6 Antibody (Tubulin beta 6) |
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| F41790-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
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Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity). |
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Tubulin beta 8 Antibody (TUBB8) |
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| F42844-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
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Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity). |
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TUBB8 Antibody (Tubulin beta 8) |
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| F42844-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 322.15 |
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Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity). |
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Tubulin beta 3 Antibody (TUBB3) |
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| F49314-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
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Description: Beta III tubulin is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development. As exemplified in cerebellar and sympathoadrenal neurogenesis, the distribution of beta III is neuron-associated, exhibiting distinct temporospatial gradients according to the regional neuroepithelia of origin. However, transient expression of this protein is also present in the subventricular zones of the CNS comprising putative neuronal- and/or glial precursor cells, as well as in Kulchitsky neuroendocrine cells of the fetal respiratory epithelium. This temporally restricted, potentially non-neuronal expression may have implications in the identification of presumptive neurons derived from embryonic stem cells. |
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Tubulin beta 1 Antibody (TUBB1) |
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| F40185-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 140.25 |
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Description: This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Tubulin beta-1 chain is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y. |
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Ocena odpowiedzi immunogennej na nowatorską szczepionkę z koniugatem enterobaktyny u kurcząt do produkcji przeciwciał żółtka jaja specyficznych dla enterobaktyny
- Passive immunization with particular egg yolk antibodies (immunoglobulin Y, IgY) is rising as a promising various to antibiotics to manage bacterial infections. Lately, we developed a novel conjugate vaccine that might set off a robust immune response in rabbits directed towards enterobactin (Ent), a extremely conserved siderophore molecule utilized by completely different Gram-negative pathogens. Nevertheless, induction of Ent-specific antibodies seemed to be affected by the selection of animal host and vaccination routine.
- It’s nonetheless unknown if the Ent conjugate vaccine can set off a selected immune response in layers for the aim of manufacturing of anti-Ent egg yolk IgY. On this research, three hen vaccination trials with completely different regimens have been carried out to find out circumstances for environment friendly manufacturing of anti-Ent egg yolk IgY. Purified Ent was conjugated to 3 provider proteins, keyhole limpet hemocyanin (KLH), bovine serum albumin (BSA) and CmeC (a subunit vaccine candidate), respectively.
- Intramuscular immunization of Barred Rock layers with KLH-Ent conjugate 4 instances induced sturdy immune response towards entire conjugate vaccine however the titer of Ent-specific IgY didn’t change in yolk with solely a four fold improve detected in serum. Within the second trial, three completely different Ent conjugate vaccines have been evaluated in Rhode Island Crimson pullets with 4 subcutaneous injections. The KLH-Ent or CmeC-Ent conjugate persistently induced excessive degree of Ent-specific IgY in each serum (as much as 2,048 fold) and yolk (as much as 1,024 fold) in every particular person hen. Nevertheless, the Ent-specific immune response was solely quickly and reasonably induced utilizing a BSA-Ent vaccination.
- Within the third trial, ten White Leghorn layers have been subcutaneously immunized thrice with KLH-Ent, resulting in constant and robust immune response towards each entire conjugate and the Ent molecule in every hen; the imply titer of Ent-specific IgY elevated roughly 32 and 256 fold in serum and yolk, respectively. According to its potent binding to numerous Ent derivatives, the Ent-specific egg yolk IgY additionally inhibited in vitro progress of a consultant Escherichia coli pressure.
- Collectively, this research demonstrated that the novel Ent conjugate vaccine might induce sturdy, particular, and sturdy immune response in chickens. The Ent-specific hyperimmune egg yolk IgY has potential for passive immune intervention towards Gram-negative infections.
Korelacja odpowiedzi na szczepionki
Introduction: The humoral response to vaccinations varies extensively between people. There isn’t a information obtainable on the correlation between responses to completely different vaccines. On this research, we investigated the correlation of antibody responses between routine vaccine antigens in infants.
Strategies: One and 7 months after the 6-month vaccinations and one month after the 12-month vaccinations, antibody concentrations to diphtheria, tetanus, pertussis, polio (serotypes 1-3), Haemophilus influenzae sort b (Hib), pneumococcus (13 serotypes), meningococcus C, measles, mumps and rubella have been measured utilizing fluorescent bead-based multiplex immune-assays. For the correlation of antibody responses, Spearman’s rank correlation coefficients (ρ) with 95% confidence intervals (CI) have been calculated between responses to every vaccine antigen.
Outcomes: The correlation between concentrations of antibodies to the vaccinations ending at 6 months of age was greater one month in comparison with seven months after vaccination. The strongest correlations at each time factors have been noticed between antibody responses to completely different polio serotypes, sure pneumococcal serotypes and between responses to diphtheria and pneumococcal (conjugated to a diphtheria toxoid) vaccine antigens. Correlation between responses to tetanus, Hib, pertussis, polio and different vaccine antigens have been weak. The correlation between antibody responses to the 12-month vaccine antigens was weaker than to the 6-month vaccine antigens and there was a adverse correlation between responses to measles, mumps, rubella vaccine and non-live vaccine antigens (meningococcus C, tetanus and Hib). There was solely weak correlation between antibody responses to vaccines of the identical sort (e.g. conjugated polysaccharide or toxoid vaccines).
Conclusion: Correlation between antibody responses to related antigens in the identical vaccine (equivalent to completely different serotypes of a micro organism or virus), in addition to responses to antigens conjugated to related provider proteins, are sturdy. In distinction, correlation between responses to different vaccines are weak. Measuring antibody responses to at least one or a number of vaccine antigens subsequently doesn’t supply a dependable surrogate marker of responses to unrelated vaccines.
Nowatorski automatyczny check immunologiczny dla przeciwciał NY-ESO-1 i XAGE1 w surowicy w skojarzonym przewidywaniu odpowiedzi na terapię przeciw zaprogramowanej śmierci komórkowej – 1 w niedrobnokomórkowym raku płuca
Background: Anti-programmed cell death-1 (PD-1) antibodies (Abs) are key medication in non-small-cell lung most cancers (NSCLC) remedy; nonetheless, medical advantages with anti-PD-1 monotherapy are restricted. We reported that serum Abs towards cancer-testis antigens NY-ESO-1 and XAGE1 predicted medical advantages. We aimed to develop a totally automated immunoassay system measuring NY-ESO-1/XAGE1 Abs.
Strategies: Sera from 30 NSCLC sufferers earlier than anti-PD-1 monotherapy have been reacted with recombinant NY-ESO-1 protein- or artificial XAGE1 peptide-coated magnetic beads. ALP-conjugated Ab and chemiluminescent substrate have been added and luminescence measured. These procedures have been automated utilizing excessive sensitivity chemiluminescent enzyme immunoassay (HISCLTM). NY-ESO-1/XAGE1 Ab stability was examined beneath numerous circumstances. Response prediction accuracy was evaluated utilizing space beneath receiver working curve (AUROC).
Outcomes: HISCL detected particular serum NY-ESO-1/XAGE1 Abs, which ranges in ELISA and HISCL have been extremely correlated. The Ab ranges in HISCL have been secure at 4 temperatures, 5 freeze/thaw cycles, and long-term storage; the degrees weren’t interfered by frequent blood elements. The Ab ranges in 15 NSCLC responders to anti-PD-1 monotherapy have been considerably greater than these in non-responders and wholesome donors. The AUROC was the best (0.91; 95% CI, 0.78-1.0) in combinatory prediction with NY-ESO-1/XAGE1 Abs.
Conclusion: Our immunoassay system is beneficial to foretell medical advantages with NSCLC immune-checkpoint remedy.
