Bodies Revealed Immunohistochemia i anatomopatologia

Białko mitochondrialne CMPK2 reguluje tworzenie

• Adam
• 19 maja, 202130 kwietnia, 2021
• 0

Białko mitochondrialne CMPK2 reguluje tworzenie komórek piankowatych wzmocnionych przez IFN alfa, potencjalnie przyczyniając się do przedwczesnej miażdżycy tętnic w SLE 

Background: Untimely atherosclerosis happens in sufferers with SLE; nonetheless, the mechanisms stay unclear. Each mitochondrial equipment and proinflammatory cytokine interferon alpha (IFN-α) probably contribute to atherogenic processes in SLE. Right here, we discover the roles of the mitochondrial protein cytidine/uridine monophosphate kinase 2 (CMPK2) in IFN-α-mediated pro-atherogenic occasions.

Strategies: Foam cell measurements have been carried out by oil purple O staining, Dil-oxLDL uptake and the BODIPY strategy. The mRNA and protein ranges have been measured by qPCR and Western blotting, respectively. Isolation of CD4+ T cells and monocytes was carried out with monoclonal antibodies conjugated with microbeads. Manipulation of protein expression was performed by both small interference RNA (siRNA) knockdown or CRISPR/Cas9 knockout. The expression of mitochondrial reactive oxygen species (mtROS) was decided by circulate cytometry and confocal microscopy.

Outcomes: IFN-α enhanced oxLDL-induced foam cell formation and Dil-oxLDL uptake by macrophages. Along with IFN-α, a number of triggers of atherosclerosis, together with thrombin and IFN-γ, can induce CMPK2 expression, which was elevated in CD4+ T cells and CD14+ monocytes remoted from SLE sufferers in comparison with these remoted from controls. The evaluation of mobile subfractions revealed that CMPK2 was current in each mitochondrial and cytosolic fractions. IFN-α-induced CMPK2 expression was inhibited by Janus kinase (JAK)half of and tyrosine kinase 2 (Tyk2) inhibitors. Each the knockdown and knockout of CMPK2 attenuated IFN-α-mediated foam cell formation, which concerned the discount of scavenger receptor class A (SR-A) expression. CMPK2 additionally regulated IFN-α-enhanced mtROS manufacturing and inflammasome activation.

Conclusions: The research means that CMPK2 performs contributing roles within the pro-atherogenic results of IFN-α.

ELISA kit for Human Tubulin beta-4 chain (TUBB4)
KTE60116-48T	Abbkine	48T	EUR 398.4
Description: Quantitative sandwich ELISA for measuring Human Tubulin beta-4 chain (TUBB4) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Tubulin beta-4 chain (TUBB4)
KTE60116-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2538
Description: Quantitative sandwich ELISA for measuring Human Tubulin beta-4 chain (TUBB4) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Tubulin beta-4 chain (TUBB4)
KTE60116-96T	Abbkine	96T	EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human Tubulin beta-4 chain (TUBB4) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Beta Tubulin Antibody / TUBB1
RQ5777	NSJ Bioreagents	100 ug	EUR 356.15
Description: TUBB1 is a gene that codes for the protein Tubulin beta-1 chain in humans. This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.

Beta Tubulin Antibody / TUBB3
V7658-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation.

Beta Tubulin Antibody / TUBB3
V7658-20UG	NSJ Bioreagents	20 ug	EUR 153.3
Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation.

Beta Tubulin Antibody / TUBB3
V7658SAF-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation.

Beta Tubulin Antibody / TUBB3
V7659-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation.

Beta Tubulin Antibody / TUBB3
V7659-20UG	NSJ Bioreagents	20 ug	EUR 153.3
Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation.

Beta Tubulin Antibody / TUBB3
V7659SAF-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3.In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation.

Beta Tubulin Antibody / TUBB3
V8309-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord. [UniProt]

Beta Tubulin Antibody / TUBB3
V8309-20UG	NSJ Bioreagents	20 ug	EUR 153.3
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord. [UniProt]

Beta Tubulin Antibody / TUBB3
V8309SAF-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord. [UniProt]

beta I Tubulin (TUBB1) Antibody
20-abx219168	Abbexa	EUR 510.00 EUR 410.40	100 ug 50 ug

Tubulin Beta 1 (TUBB1) Antibody
20-abx318661	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 3 (TUBB3) Antibody
20-abx134678	Abbexa	EUR 427.20 EUR 644.40 EUR 260.40	100 ul 200 ul 30 ul

Tubulin Beta 3 (TUBB3) Antibody
20-abx134679	Abbexa	EUR 427.20 EUR 644.40 EUR 260.40	100 ul 200 ul 30 ul

Tubulin Beta 3 (TUBB3) Antibody
20-abx134680	Abbexa	EUR 427.20 EUR 644.40 EUR 260.40	100 ul 200 ul 30 ul

Tubulin Beta 3 (TUBB3) Antibody
20-abx134681	Abbexa	EUR 427.20 EUR 644.40 EUR 260.40	100 ul 200 ul 30 ul

Tubulin Beta 3 (TUBB3) Antibody
20-abx134683	Abbexa	EUR 427.20 EUR 644.40 EUR 260.40	100 ul 200 ul 30 ul

Tubulin Beta 3 (TUBB3) Antibody
20-abx242446	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Tubulin Beta 1 (TUBB1) Antibody
abx224141-100ug	Abbexa	100 ug	EUR 493.2

Tubulin Beta 3 (TUBB3) Antibody
20-abx110304	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 3 (TUBB3) Antibody
20-abx110305	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 1 (TUBB1) Antibody
20-abx110582	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 3 (TUBb3) Antibody
20-abx174960	Abbexa	EUR 1028.40 EUR 526.80	1 mg 200 ug

Tubulin Beta 1 (TUBb1) Antibody
20-abx178748	Abbexa	EUR 1479.60 EUR 710.40	1 mg 200 ug

Tubulin Beta 3 (TUBB3) Antibody
20-abx121803	Abbexa	EUR 360.00 EUR 526.80 EUR 226.80	100 ul 200 ul 30 ul

Tubulin, Beta 3 (TUBB3) Antibody
20-abx116351	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Tubulin Beta 3 (TUBB3) Antibody
abx332407-100ul	Abbexa	100 ul	EUR 510

Tubulin Beta 3 (TUBB3) Antibody
20-abx330237	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Tubulin Beta 3 (TUBB3) Antibody
abx331438-100ul	Abbexa	100 ul	EUR 510

Tubulin Beta 3 (TUBB3) Antibody
20-abx326995	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Tubulin Beta 3 (TUBB3) Antibody
20-abx326998	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Tubulin Beta 6 (TUBB6) Antibody
abx026508-400ul	Abbexa	400 ul	EUR 627.6

Tubulin Beta 6 (TUBB6) Antibody
abx026508-80l	Abbexa	80 µl	EUR 343.2

Tubulin Beta 3 (TUBB3) Antibody
abx032605-400ul	Abbexa	400 ul	EUR 627.6

Tubulin Beta 3 (TUBB3) Antibody
abx032605-80l	Abbexa	80 µl	EUR 343.2

Tubulin Beta 3 (TUBB3) Antibody
abx036052-100ug	Abbexa	100 ug	EUR 469.2

Tubulin Beta 3 (TUBB3) Antibody
abx019140-100ug	Abbexa	100 ug	EUR 410.4

Tubulin Beta 3 (TUBB3) Antibody
abx019141-100ug	Abbexa	100 ug	EUR 410.4

Tubulin Beta 1 (TUBB1) Antibody
20-abx101412	Abbexa	EUR 526.80 EUR 159.60 EUR 1479.60 EUR 710.40 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Tubulin Beta 3 (TUBB3) Antibody
20-abx101413	Abbexa	EUR 510.00 EUR 159.60 EUR 1446.00 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Tubulin Beta 6 (TUBB6) Antibody
20-abx101414	Abbexa	EUR 526.80 EUR 159.60 EUR 1479.60 EUR 710.40 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Tubulin Beta 3 (TUBB3) Antibody
abx127119-50ul	Abbexa	50 ul	EUR 493.2

Tubulin Beta 1 (TUBB1) Antibody
20-abx129118	Abbexa	EUR 510.00 EUR 159.60 EUR 1446.00 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Tubulin Beta 3 (TUBB3) Antibody
20-abx123449	Abbexa	EUR 710.40 EUR 1028.40 EUR 260.40 EUR 493.20	100 ul 200 ul 20 ul 50 ul

Tubulin Beta 6 (TUBB6) Antibody
abx340217-100ug	Abbexa	100 ug	EUR 469.2

Tubulin Beta 3 (TUBB3) Antibody
abx431689-200ul	Abbexa	200 ul	EUR 460.8

Tubulin Beta 1 (TUBB1) Antibody
20-abx005943	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Tubulin Beta 3 (TUBB3) Antibody
20-abx002044	Abbexa	EUR 493.20 EUR 710.40 EUR 376.80	100 ul 200 ul 50 ul

Tubulin Beta 3 (TUBB3) Antibody
abx012294-100ul	Abbexa	100 ul	EUR 493.2

Tubulin Beta 1 (TUBB1) Antibody
abx145776-100ug	Abbexa	100 ug	EUR 469.2

Tubulin Beta 6 (TUBB6) Antibody
20-abx302860	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 2B (TUBB2B) Antibody
20-abx137361	Abbexa	EUR 844.80 EUR 393.60 EUR 276.00	100 ug 20 ug 5 ug

Tubulin Beta 2A (TUBB2A) Antibody
20-abx246726	Abbexa	EUR 627.60 EUR 343.20	200 ul 50 ul

Tubulin, Beta 2B (TUBB2B) Antibody
20-abx116350	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Tubulin Beta 2A (TUBB2A) Antibody
20-abx326997	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Tubulin Beta 2A (TUBB2A) Antibody
20-abx109386	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 2B (TUBB2B) Antibody
abx026514-400ul	Abbexa	400 ul	EUR 627.6

Tubulin Beta 2B (TUBB2B) Antibody
abx026514-80l	Abbexa	80 µl	EUR 343.2

Tubulin Beta 2A (TUBB2A) Antibody
abx027572-400ul	Abbexa	400 ul	EUR 627.6

Tubulin Beta 2A (TUBB2A) Antibody
abx027572-80l	Abbexa	80 µl	EUR 343.2

Tubulin Beta 2A (TUBB2A) Antibody
abx016016-100ug	Abbexa	100 ug	EUR 493.2

Tubulin Beta 2B (TUBB2B) Antibody
abx145775-100ug	Abbexa	100 ug	EUR 469.2

Tubulin Beta 2A (TUBB2A) Antibody
abx145790-100ug	Abbexa	100 ug	EUR 469.2

beta IV Tubulin antibody
22498-100ul	SAB	100ul	EUR 468

Beta Tubulin Antibody / TUBB
F54148-0.05ML	NSJ Bioreagents	0.05 ml	EUR 140.25
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Beta Tubulin Antibody / TUBB
F54148-0.2ML	NSJ Bioreagents	0.2 ml	EUR 322.15
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Beta Tubulin Antibody / TUBB
RQ5179	NSJ Bioreagents	100ul	EUR 356.15
Description: The TUBB gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [RefSeq]

Beta Tubulin Antibody / TUBB
RQ6081	NSJ Bioreagents	100 ug	EUR 356.15
Description: Tubulin beta chain is a protein that in humans is encoded by the TUBB gene. This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13.

Tubulin beta 1 Antibody (TUBB1)
F51482-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Tubulin beta-1 chain (TUBB1) is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release.

Tubulin beta 1 Antibody (TUBB1)
F40185-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Tubulin beta-1 chain is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.

Tubulin beta 1 Antibody (TUBB1)
F40189-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

TUBB6 Antibody (Tubulin beta 6)
F41790-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity).

TUBB6 Antibody (Tubulin beta 6)
F41790-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity).

Tubulin beta 8 Antibody (TUBB8)
F42844-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity).

TUBB8 Antibody (Tubulin beta 8)
F42844-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity).

Tubulin beta 3 Antibody (TUBB3)
F49314-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: Beta III tubulin is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development. As exemplified in cerebellar and sympathoadrenal neurogenesis, the distribution of beta III is neuron-associated, exhibiting distinct temporospatial gradients according to the regional neuroepithelia of origin. However, transient expression of this protein is also present in the subventricular zones of the CNS comprising putative neuronal- and/or glial precursor cells, as well as in Kulchitsky neuroendocrine cells of the fetal respiratory epithelium. This temporally restricted, potentially non-neuronal expression may have implications in the identification of presumptive neurons derived from embryonic stem cells.

Tubulin beta 3 Antibody / TUBB3
R32611	NSJ Bioreagents	100 ug	EUR 356.15
Description: Tubulin beta-3 chain is a protein that in humans is encoded by the TUBB3 gene. This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6.

Tubulin Beta (TUBB) Antibody
abx246727-100ul	Abbexa	100 ul	EUR 627.6

Tubulin Beta (TUBB) Antibody
abx246728-100ul	Abbexa	100 ul	EUR 627.6

Tubulin Beta (TUBB) Antibody
abx246729-100ul	Abbexa	100 ul	EUR 627.6

Tubulin Beta (TUBB) Antibody
abx246734-400ul	Abbexa	400 ul	EUR 678

Tubulin Beta (TUBB) Antibody
abx246734-80l	Abbexa	80 µl	EUR 360

Tubulin Beta (TUBB) Antibody
20-abx249495	Abbexa	EUR 376.80 EUR 117.60 EUR 477.60 EUR 594.00	100 ug 10 ug 200 ug 300 µg

Tubulin Beta (TUBB) Antibody
abx230879-100ug	Abbexa	100 ug	EUR 610.8

Tubulin Beta (TUBB) Antibody
abx230880-100ug	Abbexa	100 ug	EUR 610.8

Tubulin Beta (TUBB) Antibody
abx219172-100ug	Abbexa	100 ug	EUR 526.8

Tubulin Beta (TUBB) Antibody
20-abx110666	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta (TUBB) Antibody
20-abx110667	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta (TUBB) Antibody
abx139403-01mg	Abbexa	0.1 mg	EUR 477.6

Tubulin Beta (TUBB) Antibody
20-abx132236	Abbexa	EUR 410.40 EUR 1045.20 EUR 543.60 EUR 184.80 EUR 326.40	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta (TUBB) Antibody
20-abx132255	Abbexa	EUR 510.00 EUR 159.60 EUR 1412.40 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Tubulin Beta (TUBB) Antibody
20-abx132364	Abbexa	EUR 393.60 EUR 978.00 EUR 510.00 EUR 184.80 EUR 309.60	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin, Beta (TUBB) Antibody
20-abx116349	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Tubulin Beta (TUBB) Antibody
20-abx118008	Abbexa	EUR 661.20 EUR 577.20	100 ul 50 ul

Tubulin Beta (TUBB) Antibody
20-abx121030	Abbexa	EUR 360.00 EUR 526.80 EUR 226.80	100 ul 200 ul 30 ul

Tubulin Beta (TUBB) Antibody
abx025155-400ul	Abbexa	400 ul	EUR 627.6

Tubulin Beta (TUBB) Antibody
abx025155-80l	Abbexa	80 µl	EUR 343.2

Tubulin Beta (TUBB) Antibody
abx018233-100ug	Abbexa	100 ug	EUR 460.8

Tubulin Beta (TUBB) Antibody
abx018336-100ug	Abbexa	100 ug	EUR 526.8

Tubulin Beta (TUBB) Antibody
abx019025-100ug	Abbexa	100 ug	EUR 385.2

Tubulin Beta (TUBB) Antibody
20-abx019026	Abbexa	EUR 385.20 EUR 142.80	100 ug 10 ug

Tubulin Beta (TUBB) Antibody
abx019185-100ug	Abbexa	100 ug	EUR 410.4

Tubulin Beta (TUBB) Antibody
abx037893-100ug	Abbexa	100 ug	EUR 469.2

Tubulin Beta (TUBB) Antibody
abx037894-100ug	Abbexa	100 ug	EUR 469.2

Tubulin Beta (TUBB) Antibody
20-abx101054	Abbexa	EUR 493.20 EUR 159.60 EUR 1378.80 EUR 678.00 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Tubulin Beta (TUBB) Antibody
20-abx124984	Abbexa	EUR 427.20 EUR 594.00	100 ul 200 ul

Tubulin Beta (TUBB) Antibody
20-abx005574	Abbexa	EUR 376.80 EUR 493.20 EUR 309.60	100 ul 200 ul 50 ul

Tubulin Beta (TUBB) Antibody
abx012291-100ug	Abbexa	100 ug	EUR 526.8

Tubulin Beta (TUBB) Antibody
20-abx013240	Abbexa	EUR 376.80 EUR 117.60 EUR 477.60 EUR 594.00	100 ug 10 ug 200 ug 300 µg

Tubulin Beta (TUBB) Antibody
abx145777-100ug	Abbexa	100 ug	EUR 469.2

beta 3-Tubulin (TUBB3) Antibody
20-abx134677	Abbexa	EUR 427.20 EUR 644.40 EUR 260.40	100 ul 200 ul 30 ul

beta 3-Tubulin (TUBB3) Antibody
20-abx134682	Abbexa	EUR 427.20 EUR 644.40 EUR 260.40	100 ul 200 ul 30 ul

beta 1-Tubulin (TUBB1) Antibody
20-abx134686	Abbexa	EUR 427.20 EUR 644.40 EUR 260.40	100 ul 200 ul 30 ul

beta 1-Tubulin (TUBB1) Antibody
20-abx134687	Abbexa	EUR 427.20 EUR 644.40 EUR 260.40	100 ul 200 ul 30 ul

Tubulin beta 4Q Antibody (TUBB4Q)
F52213-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity).

TUBB4Q Antibody (Tubulin beta 4Q)
F52213-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity).

Tubulin beta 2A Antibody / TUBB2A
F54147-0.05ML	NSJ Bioreagents	0.05 ml	EUR 140.25
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

Tubulin beta 2A Antibody / TUBB2A
F54147-0.2ML	NSJ Bioreagents	0.2 ml	EUR 322.15
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

TUBB8B Antibody (Tubulin beta 8B)
F41793-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.

TUBB8B Antibody (Tubulin beta 8B)
F41793-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.

TUBB2B Antibody (Tubulin beta 2B)
F41797-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq].

TUBB2B Antibody (Tubulin beta 2B)
F41797-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq].

Tubulin beta 2A Antibody (TUBB2A)
F43212-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity).

TUBB2A Antibody (Tubulin beta 2A)
F43212-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity).

Tubulin beta 2C Antibody (TUBB2C)
F49034-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: TUBB2C is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.

TUBB2C Antibody (Tubulin beta 2C)
F49034-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: TUBB2C is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.

Beta III Tubulin Antibody (TUBB3)
F49314-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: Beta III tubulin is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development. As exemplified in cerebellar and sympathoadrenal neurogenesis, the distribution of beta III is neuron-associated, exhibiting distinct temporospatial gradients according to the regional neuroepithelia of origin. However, transient expression of this protein is also present in the subventricular zones of the CNS comprising putative neuronal- and/or glial precursor cells, as well as in Kulchitsky neuroendocrine cells of the fetal respiratory epithelium. This temporally restricted, potentially non-neuronal expression may have implications in the identification of presumptive neurons derived from embryonic stem cells.

Tubulin Beta 6 (TUBB6) Antibody (HRP)
20-abx311512	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 3 (TUBB3) Antibody (HRP)
20-abx108851	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 3 (TUBB3) Antibody (HRP)
20-abx108852	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 1 (TUBB1) Antibody (HRP)
20-abx109143	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 1 (TUBB1) Antibody (HRP)
20-abx310961	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 6 (TUBB6) Antibody (FITC)
20-abx311513	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 3 (TUBb3) Antibody (FITC)
20-abx271228	Abbexa	EUR 577.20 EUR 292.80 EUR 1696.80 EUR 794.40 EUR 427.20	100 ug 10 ug 1 mg 200 ug 50 ug

Tubulin Beta 3 (TUBB3) Antibody (FITC)
20-abx107431	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 3 (TUBB3) Antibody (FITC)
20-abx107432	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 3 (TUBB3) Antibody Pair
abx117637-1pair5x96wellplates	Abbexa	1 pair (5x96 well plates)	EUR 1212

Tubulin Beta 1 (TUBb1) Antibody Pair
20-abx370772	Abbexa	EUR 1996.80 EUR 1279.20	10 × 96 tests 5 × 96 tests

Tubulin Beta 1 (TUBB1) Antibody (FITC)
20-abx107725	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 2A (TUBB2A) Antibody (HRP)
20-abx108850	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 1 (TUBB1) Antibody (FITC)
20-abx310962	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 2A (TUBB2A) Antibody (FITC)
20-abx107430	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 6 (TUBB6) Antibody (Biotin)
20-abx311514	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 3 (TUBb3) Antibody (Biotin)
20-abx271494	Abbexa	EUR 543.60 EUR 292.80 EUR 1579.20 EUR 744.00 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Tubulin Beta 1 (TUBB1) Antibody (Biotin)
20-abx106312	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 3 (TUBB3) Antibody (Biotin)
20-abx106017	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 3 (TUBB3) Antibody (Biotin)
20-abx106018	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 6 (TUBb6) Antibody (Biotin)
20-abx274250	Abbexa	EUR 560.40 EUR 292.80 EUR 1612.80 EUR 760.80 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Tubulin Beta 1 (TUBB1) Antibody (Biotin)
20-abx310963	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta 2A (TUBB2A) Antibody (Biotin)
20-abx106016	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta-8 Chain (TUBB8) Antibody
abx027305-400ul	Abbexa	400 ul	EUR 627.6

Tubulin Beta-8 Chain (TUBB8) Antibody
abx027305-80l	Abbexa	80 µl	EUR 343.2

Tubulin Beta-8 Chain (TUBB8) Antibody
20-abx006140	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Active Tubulin Beta (TUBb)
4-APB870Hu01	Cloud-Clone	EUR 1010.27 EUR 393.60 EUR 3458.50 EUR 1232.83 EUR 2345.66 EUR 751.20 EUR 8466.24	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tubulin Beta expressed in: E.coli

Recombinant Tubulin Beta 1 (TUBb1)
4-RPE707Hu01	Cloud-Clone	EUR 550.08 EUR 271.20 EUR 1732.80 EUR 657.60 EUR 1195.20 EUR 444.00 EUR 4152.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tubulin Beta 1 expressed in: E.coli

Recombinant Tubulin Beta 1 (TUBb1)
4-RPE707Mu01	Cloud-Clone	EUR 625.34 EUR 290.40 EUR 2015.04 EUR 751.68 EUR 1383.36 EUR 494.40 EUR 4857.60	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Tubulin Beta 1 expressed in: E.coli

Recombinant Tubulin Beta 3 (TUBb3)
4-RPE711Hu01	Cloud-Clone	EUR 614.59 EUR 288.00 EUR 1974.72 EUR 738.24 EUR 1356.48 EUR 487.20 EUR 4756.80	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tubulin Beta 3 expressed in: E.coli

Recombinant Tubulin Beta 6 (TUBb6)
4-RPE712Mu01	Cloud-Clone	EUR 603.84 EUR 285.60 EUR 1934.40 EUR 724.80 EUR 1329.60 EUR 480.00 EUR 4656.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Tubulin Beta 6 expressed in: E.coli

Tubulin Beta (TUBB) Antibody (HRP)
20-abx134684	Abbexa	EUR 460.80 EUR 727.20 EUR 276.00	100 ul 200 ul 30 ul

Polyclonal TUBB / Beta Tubulin Antibody
APR13864G	Leading Biology	0.05ml	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TUBB / Beta Tubulin . This antibody is tested and proven to work in the following applications:

Monoclonal TUBB / Beta Tubulin Antibody
APR13865G	Leading Biology	0.05ml	EUR 580.8
Description: A Monoclonal antibody against Human TUBB / Beta Tubulin. The antibodies are raised in Mouse. This antibody is applicable in WB and IHC-P, IF

Tubulin Beta-2C Chain (TUBB2C) Antibody
abx032420-400ul	Abbexa	400 ul	EUR 627.6

Tubulin Beta-2C Chain (TUBB2C) Antibody
abx032420-80l	Abbexa	80 µl	EUR 343.2

Tubulin Beta-4B Chain (TUBB4B) Antibody
20-abx125403	Abbexa	EUR 594.00 EUR 844.80 EUR 427.20	100 ul 200 ul 50 ul

Tubulin Beta-2C Chain (TUBB2C) Antibody
abx340218-100ug	Abbexa	100 ug	EUR 469.2

Tubulin Beta-4A Chain (TUBB4A) Antibody
20-abx302623	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Tubulin Beta (TUBB) CLIA Kit
20-abx493193	Abbexa	EUR 10282.80 EUR 5472.00 EUR 1262.40	10 × 96 tests 5 × 96 tests 96 tests

Mouse Tubulin Beta 1 (TUBB1) Protein
20-abx069519	Abbexa	EUR 878.40 EUR 343.20 EUR 2715.60 EUR 1045.20 EUR 627.60	100 ug 10 ug 1 mg 200 ug 50 ug

Human Tubulin Beta 3 (TUBB3) Protein
20-abx069520	Abbexa	EUR 861.60 EUR 343.20 EUR 2665.20 EUR 1028.40 EUR 610.80	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Tubulin Beta 6 (TUBB6) Protein
20-abx069521	Abbexa	EUR 844.80 EUR 343.20 EUR 2598.00 EUR 994.80 EUR 594.00	100 ug 10 ug 1 mg 200 ug 50 ug

Human Tubulin Beta 1 (TUBB1) Protein
20-abx166510	Abbexa	EUR 777.60 EUR 326.40 EUR 2331.60 EUR 910.80 EUR 560.40	100 ug 10 ug 1 mg 200 ug 50 ug

Human Tubulin beta-3 chain (TUBB3)
1-CSB-RP038744h	Cusabio	EUR 456.00 EUR 256.80 EUR 1570.80 EUR 672.00 EUR 1047.60 EUR 314.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Tubulin beta-3 chain(TUBB3),partial expressed in E.coli

Human Tubulin beta-6 chain (TUBB6)
1-CSB-EP880105HU	Cusabio	EUR 456.00 EUR 256.80 EUR 1570.80 EUR 672.00 EUR 1047.60 EUR 314.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Tubulin beta-6 chain(TUBB6) expressed in E.coli

Rabbit Anti-Human tubulin, beta 1 (TUBB1) IgG (aff pure)
AB-23096-A	Alpha Diagnostics	100ug	EUR 578.4

Mouse Monoclonal Anti-Human Tubulin, beta 3 (TUBB3) IgG
MA-20374	Alpha Diagnostics	100 ul	EUR 518.4

Tubulin Beta (TUBB) ELISA Kit
20-abx156857	Abbexa	EUR 8684.40 EUR 4626.00 EUR 1074.00	10 × 96 tests 5 × 96 tests 96 tests

Tubulin Beta 1 Class VI (TUBB1) Antibody
20-abx159741	Abbexa	EUR 326.40 EUR 276.00	100 ug 50 ug

Tubulin Beta 1 Class VI (TUBB1) Antibody
20-abx159742	Abbexa	EUR 326.40 EUR 276.00	100 ug 50 ug

Tubulin Beta 1 Class VI (TUBB1) Antibody
abx159743-100ul	Abbexa	100 ul	EUR 427.2

Tubulin Beta 1 Class VI (TUBB1) Antibody
abx159744-100ul	Abbexa	100 ul	EUR 427.2

Cow Tubulin Beta 3 (TUBB3) ELISA Kit
abx518029-96tests	Abbexa	96 tests	EUR 1093.2

Rat Tubulin Beta 3 (TUBB3) ELISA Kit
abx518032-96tests	Abbexa	96 tests	EUR 801.6

Pig Tubulin Beta 5 (TUBB5) ELISA Kit
abx518666-96tests	Abbexa	96 tests	EUR 1093.2

Rat Tubulin Beta 3 (TUBb3) ELISA Kit
RDR-TUBb3-Ra-48T	Reddot Biotech	48T	EUR 512
Description: tissue homogenates, cell lysates and other biological fluids.

Rat Tubulin Beta 3 (TUBb3) ELISA Kit
RDR-TUBb3-Ra-96T	Reddot Biotech	96T	EUR 731.5
Description: tissue homogenates, cell lysates and other biological fluids.

Rat Tubulin Beta 3 (TUBb3) ELISA Kit
RD-TUBb3-Ra-48T	Reddot Biotech	48T	EUR 487.7
Description: tissue homogenates, cell lysates and other biological fluids.

Rat Tubulin Beta 3 (TUBb3) ELISA Kit
RD-TUBb3-Ra-96T	Reddot Biotech	96T	EUR 696.7
Description: tissue homogenates, cell lysates and other biological fluids.

Recombinant Tubulin Beta (TUBb)
4-RPB870Hu01	Cloud-Clone	EUR 614.59 EUR 288.00 EUR 1974.72 EUR 738.24 EUR 1356.48 EUR 487.20 EUR 4756.80	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tubulin Beta expressed in: E.coli

Mouse Tubulin Beta 1 (TUBB1) CLIA Kit
20-abx494707	Abbexa	EUR 9567.60 EUR 5095.20 EUR 1177.20	10 × 96 tests 5 × 96 tests 96 tests

Human Tubulin Beta 3 (TUBB3) CLIA Kit
20-abx494708	Abbexa	EUR 9567.60 EUR 5095.20 EUR 1177.20	10 × 96 tests 5 × 96 tests 96 tests

Human Tubulin Beta 1 (TUBB1) CLIA Kit
20-abx496423	Abbexa	EUR 9567.60 EUR 5095.20 EUR 1177.20	10 × 96 tests 5 × 96 tests 96 tests

Human Tubulin beta-2A chain (TUBB2A)
1-CSB-YP025320HU	Cusabio	EUR 516.00 EUR 280.80 EUR 1809.60 EUR 770.40 EUR 1210.80 EUR 349.20	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Tubulin beta-2A chain(TUBB2A) expressed in Yeast

Ocena odpowiedzi immunogennej na nowatorską szczepionkę z koniugatem enterobaktyny u kurcząt do produkcji przeciwciał żółtka jaja specyficznych dla enterobaktyny

• Passive immunization with particular egg yolk antibodies (immunoglobulin Y, IgY) is rising as a promising various to antibiotics to manage bacterial infections. Lately, we developed a novel conjugate vaccine that might set off a robust immune response in rabbits directed towards enterobactin (Ent), a extremely conserved siderophore molecule utilized by completely different Gram-negative pathogens. Nevertheless, induction of Ent-specific antibodies seemed to be affected by the selection of animal host and vaccination routine.
• It’s nonetheless unknown if the Ent conjugate vaccine can set off a selected immune response in layers for the aim of manufacturing of anti-Ent egg yolk IgY. On this research, three hen vaccination trials with completely different regimens have been carried out to find out circumstances for environment friendly manufacturing of anti-Ent egg yolk IgY. Purified Ent was conjugated to 3 provider proteins, keyhole limpet hemocyanin (KLH), bovine serum albumin (BSA) and CmeC (a subunit vaccine candidate), respectively.
• Intramuscular immunization of Barred Rock layers with KLH-Ent conjugate 4 instances induced sturdy immune response towards entire conjugate vaccine however the titer of Ent-specific IgY didn’t change in yolk with solely a four fold improve detected in serum. Within the second trial, three completely different Ent conjugate vaccines have been evaluated in Rhode Island Crimson pullets with 4 subcutaneous injections. The KLH-Ent or CmeC-Ent conjugate persistently induced excessive degree of Ent-specific IgY in each serum (as much as 2,048 fold) and yolk (as much as 1,024 fold) in every particular person hen. Nevertheless, the Ent-specific immune response was solely quickly and reasonably induced utilizing a BSA-Ent vaccination.
• Within the third trial, ten White Leghorn layers have been subcutaneously immunized thrice with KLH-Ent, resulting in constant and robust immune response towards each entire conjugate and the Ent molecule in every hen; the imply titer of Ent-specific IgY elevated roughly 32 and 256 fold in serum and yolk, respectively. According to its potent binding to numerous Ent derivatives, the Ent-specific egg yolk IgY additionally inhibited in vitro progress of a consultant Escherichia coli pressure.
• Collectively, this research demonstrated that the novel Ent conjugate vaccine might induce sturdy, particular, and sturdy immune response in chickens. The Ent-specific hyperimmune egg yolk IgY has potential for passive immune intervention towards Gram-negative infections.

Korelacja odpowiedzi na szczepionki

Introduction: The humoral response to vaccinations varies extensively between people. There isn’t a information obtainable on the correlation between responses to completely different vaccines. On this research, we investigated the correlation of antibody responses between routine vaccine antigens in infants.

Strategies: One and 7 months after the 6-month vaccinations and one month after the 12-month vaccinations, antibody concentrations to diphtheria, tetanus, pertussis, polio (serotypes 1-3), Haemophilus influenzae sort b (Hib), pneumococcus (13 serotypes), meningococcus C, measles, mumps and rubella have been measured utilizing fluorescent bead-based multiplex immune-assays. For the correlation of antibody responses, Spearman’s rank correlation coefficients (ρ) with 95% confidence intervals (CI) have been calculated between responses to every vaccine antigen.

Outcomes: The correlation between concentrations of antibodies to the vaccinations ending at 6 months of age was greater one month in comparison with seven months after vaccination. The strongest correlations at each time factors have been noticed between antibody responses to completely different polio serotypes, sure pneumococcal serotypes and between responses to diphtheria and pneumococcal (conjugated to a diphtheria toxoid) vaccine antigens. Correlation between responses to tetanus, Hib, pertussis, polio and different vaccine antigens have been weak. The correlation between antibody responses to the 12-month vaccine antigens was weaker than to the 6-month vaccine antigens and there was a adverse correlation between responses to measles, mumps, rubella vaccine and non-live vaccine antigens (meningococcus C, tetanus and Hib). There was solely weak correlation between antibody responses to vaccines of the identical sort (e.g. conjugated polysaccharide or toxoid vaccines).

Conclusion: Correlation between antibody responses to related antigens in the identical vaccine (equivalent to completely different serotypes of a micro organism or virus), in addition to responses to antigens conjugated to related provider proteins, are sturdy. In distinction, correlation between responses to different vaccines are weak. Measuring antibody responses to at least one or a number of vaccine antigens subsequently doesn’t supply a dependable surrogate marker of responses to unrelated vaccines.

Nowatorski automatyczny check immunologiczny dla przeciwciał NY-ESO-1 i XAGE1 w surowicy w skojarzonym przewidywaniu odpowiedzi na terapię przeciw zaprogramowanej śmierci komórkowej – 1 w niedrobnokomórkowym raku płuca

Background: Anti-programmed cell death-1 (PD-1) antibodies (Abs) are key medication in non-small-cell lung most cancers (NSCLC) remedy; nonetheless, medical advantages with anti-PD-1 monotherapy are restricted. We reported that serum Abs towards cancer-testis antigens NY-ESO-1 and XAGE1 predicted medical advantages. We aimed to develop a totally automated immunoassay system measuring NY-ESO-1/XAGE1 Abs.

Strategies: Sera from 30 NSCLC sufferers earlier than anti-PD-1 monotherapy have been reacted with recombinant NY-ESO-1 protein- or artificial XAGE1 peptide-coated magnetic beads. ALP-conjugated Ab and chemiluminescent substrate have been added and luminescence measured. These procedures have been automated utilizing excessive sensitivity chemiluminescent enzyme immunoassay (HISCL^TM). NY-ESO-1/XAGE1 Ab stability was examined beneath numerous circumstances. Response prediction accuracy was evaluated utilizing space beneath receiver working curve (AUROC).

Outcomes: HISCL detected particular serum NY-ESO-1/XAGE1 Abs, which ranges in ELISA and HISCL have been extremely correlated. The Ab ranges in HISCL have been secure at 4 temperatures, 5 freeze/thaw cycles, and long-term storage; the degrees weren’t interfered by frequent blood elements. The Ab ranges in 15 NSCLC responders to anti-PD-1 monotherapy have been considerably greater than these in non-responders and wholesome donors. The AUROC was the best (0.91; 95% CI, 0.78-1.0) in combinatory prediction with NY-ESO-1/XAGE1 Abs.

Conclusion: Our immunoassay system is beneficial to foretell medical advantages with NSCLC immune-checkpoint remedy.